Abstract
Certain human leukocyte antigens may increase the risk of cytomegalovirus interstitial pneumonitis, an important complication of bone marrow transplantation. The prevalence of this pneumonitis was compared between patients possessing either HLA-B51 or HLA-B52 and patients without either antigen. The role of tumor necrosis factor-α in cytomegalovirus interstitial pneumonitis was also studied. Among 72 patients undergoing allogeneic bone marrow transplantation at our institution during the past 5 years, HLA-B51 or -B52 was detected in 29. Among these 29 patients, 13 (45%) developed cytomegalovirus interstitial pneumonitis, a significantly higher rate (P < 0.001) than among patients without these hla types (4/43, 9%). in the pre-conditioning and stable phases, tumor necrosis factor-α levels were higher in patients with hla-b51 or hla-b52 than in patients without (P < 0.05; t-test). Throughout the period from pre-conditioning to around day 40, except on day 0, tumor necrosis factor-α levels were also significantly higher (P < 0.05 to P < 0.001) in patients developing cytomegalovirus infection than in those without it. these results suggest that hla-b51 and hla-b52 may be risk factors for cytomegalovirus interstitial pneumonitis after bone marrow transplantation, with an increase of tumor necrosis factor-α also being involved. Bone Marrow Transplantation (2000) 25, 861–865.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Wang FZ, Dahl H, Kinde A et al. Lymphotrophic herpesvirus in allogeneic bone marrow transplantation Blood 1996 88: 3615–3620
Enright H, Haake R, Weisdorf D et al. Cytomegalovirus pneumonia after bone marrow transplantation: risk factor and response to therapy Transplantation 1993 55: 1339–1346
Kruse H, Hebart H, Jahn G et al. Screening of CMV specific T-cell proliferation to identify patients at risk of developing late onset CMV disease Bone Marrow Transplant 1997 19: 1111–1116
Gor D, Sabin C, Prentice HG et al. Longitudinal fluctuations in cytomegalovirus load in bone marrow transplant patients: relationship between peak virus load, donor/recipientserostatus, acute GVHD and CMV disease Bone MarrowTransplant 1998 21: 597–605
Takeno M, Kariyone A, Yamashita N et al. Excessive function of peripheral blood neutrophils from patients with Behcet's disease and from HLA-51 trangenic mice Arthr Rheum 1995 38: 426–433
Arber N, Klein T, Meiner Z et al. Close association of HLA-B51 and B52 in Israeli patients with Behcet's snndrome Ann Rheum Dis 1991 50: 351–353
Sakane T . New perspective on Behcet's disease Int Rev Immunol 1997 14: 89–96
Yamashita N, Kaneoka H, Kaneko S et al. Role of γ δ T lymphocytes in the development of Behcet's disease Clin Exp Immunol 1997 107: 241–247
Ehrlich GE . Vasculitis in Behcet's disease Int Rev Immunol 1997 14: 81–88
Aydintug AO, Tokgoz G, Ozoran K et al. Elevated levels of soluble intercellular adhesion molecule-1 correlate with disease activity in Behcet's disease Rheumatol Int 1995 15: 75–78
Schmidt GM, Horak DA, Niland JC et al. A randomized, controlled trial of prophylactic ganciclovir for cytomegalovirus pulmonary infection in recipients of allogeneic bone marrow transplants New Engl J Med 1991 324: 1005–1011
Gondo H, Minematsu T, Harada M et al. Cytomegalovirus (CMV) antigenemia for rapid diagnosis and monitoring of CMV-associated disease after bone marrow transplantation Br J Haematol 1994 186: 130–137
Singhal S, Mehta J, Powles R et al. Three weeks of ganciclovir for cytomegaloviraemia after allogeneic bone marrow transplantation Bone Marrow Transplant 1995 15: 777–781
Grundy JE, Shanley JD, Griffiths PD . Is cytomegalovirus interstitial pneumonitis in transplant recipients an immunopathological conditions? Lancet 1987 1: 996–998
Tanaka K, Koga Y, Lu YY et al. Murine cytomegalovirus-associated pneumonitis in the lungs free of the virus J Clin Invest 1994 94: 1019–1025
Tanaka K, Nakazawa H, Okada K et al. Nitric oxide mediates murine cytomegalovirus-associated pneumonitis in lungs that are free of the virus J Clin Invest 1997 100: 1822–1830
Orange JS, Biron CA . Characterization of early IL-12, IFN-α β, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection J Immunol 1996 156: 4746–4756
Murayama T, Kuno K, Jisaki F et al. Enhancement of human cytomegalovirus replication in a human lung fibroblast cell line by interleukin-8 J Virol 1994 68: 7582–7585
Geist LJ, Monick MM, Stinski MF, Hunnighake GW . The immediate–early genes of human cytomegalovirus upregulate tomor necrosis factor-α gene expression J Clin Invest 1994 93: 474–478
Anderson JA, Lentsch AB, Hadjiminas DJ et al. The role of cytokines, adhesion molecules, and chemokines in interleukin-2-induced lymphocytic infiltration in C57BL/6 mice J Clin Invest 1996 97: 1952–1959
Humar A, Louis PS, Mazzulli T et al. Elevated serum cytokines are associated with cytomegalovirus infection and disease in bone marrow transplant recipients J Infect Dis 1999 179: 484–488
Acknowledgements
We wish to thank Ms A Utsumi and Ms Y Shikita for their expert technical assistance.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yamada, S., Takatsuka, H., Takemoto, Y. et al. Association of cytomegalovirus interstitial pneumonitis with HLA-type following allogeneic bone marrow transplantation. Bone Marrow Transplant 25, 861–865 (2000). https://doi.org/10.1038/sj.bmt.1702244
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1702244
Keywords
This article is cited by
-
Vascular endothelial growth factor (VEGF) is associated with reduced severity of acute graft-versus-host disease and nonrelapse mortality after allogeneic stem cell transplantation
Bone Marrow Transplantation (2006)
-
Cytomegalovirus interstitial pneumonitis following allogeneic peripheral blood stem cell transplantation
Chinese Journal of Cancer Research (2005)
-
Genetic control of innate immune responses against cytomegalovirus: MCMV meets its match
Genes & Immunity (2002)
-
Oral eicosapentaenoic acid for complications of bone marrow transplantation
Bone Marrow Transplantation (2001)
-
Complications after bone marrow transplantation are manifestations of systemic inflammatory response syndrome
Bone Marrow Transplantation (2000)