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Busulfan clearance in renal failure and hemodialysis

Bone Marrow Transplantation volume 25, pages 201–203 (2000)Cite this article

Abstract

The impact of hemodialysis on the clearance of busulfan was determined in a patient with chronic renal failure undergoing autologous peripheral stem cell transplantation for non-Hodgkin's lymphoma. The extraction ratio for busulfan across the dialyzer was 0.530 ± 0.026 at a blood flow of 400 ml/min, which corresponds to a hemodialysis clearance of 2.23 ± 0.11 ml/min/kg body weight. Apparent oral clearance of busulfan without hemodialysis was 3.38 ± 0.56 ml/min/kg. Thus, a 4 h hemodialysis session enhanced the apparent oral clearance of busulfan by 65%. We conclude that hemodialysis effectively removes busulfan from circulating blood, but a standard hemodialysis period (ie, 4 h) does not significantly alter busulfan exposure. Bone Marrow Transplantation(2000) 25, 201–203.

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Acknowledgements

This work was supported in part by National Institutes of Health Grant CA18029.

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  1. St Joseph Medical Center, Tacoma, WA, USA

    LL Ullery, GW Ames & FM Senecal

  2. Department of Pharmaceutics, University of Washington, Seattle, WA, USA

    LL Ullery, JP Gibbs & JT Slattery

  3. Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    JT Slattery

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  1. LL Ullery
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  2. JP Gibbs
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Ullery, L., Gibbs, J., Ames, G. et al. Busulfan clearance in renal failure and hemodialysis. Bone Marrow Transplant 25, 201–203 (2000). https://doi.org/10.1038/sj.bmt.1702112

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