Abstract
The purpose of this study was to assess the role of ABMT in children with ALL who are in 2nd CR after an early isolated CNS relapse. All children experiencing an isolated CNS relapse at 10 AIEOP centers (Associazione Italiana Emato-Oncologia Pediatrica) from 1986 to 1992 were eligible for this study. The series included 69 patients who relapsed within 3 years from diagnosis: 19 underwent ABMT, nine patients underwent ALLO-BMT from an HLA-identical sibling, and 41 received conventional chemotherapy (CHEMO). Statistical analysis was performed using a Cox’s regression model, adjusting for the waiting time before transplantation and prognostic factors. The 5 years DFS was 56.3% (s.e. 12.3) for patients in the ABMT group. This compared favorably with the poor result (12.6% (s.e. 5.9)) seen in the CHEMO group. The risk of failures was reduced by one-third in the ABMT group as compared to the CHEMO group in the multivariate analysis (P < 0.01). in the allo group four out of nine patients were in ccr 4–5 years post-transplant. this study suggests that abmt may also represent a valuable therapeutic choice for patients lacking a matched familiar donor in 2nd cr after an early isolated cns relapse.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Consortia
Rights and permissions
About this article
Cite this article
Messina, C., Valsecchi, M., Aricò, M. et al. Autologous bone marrow transplantation for treatment of isolated central nervous system relapse of childhood acute lymphoblastic leukemia. Bone Marrow Transplant 21, 9–14 (1998). https://doi.org/10.1038/sj.bmt.1701052
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1701052
Keywords
This article is cited by
-
Hematopoietic stem cell transplantation for isolated extramedullary relapse of acute lymphoblastic leukemia in children
Bone Marrow Transplantation (2019)
-
Autologous purified peripheral blood SCT in childhood low-risk relapsed ALL
Bone Marrow Transplantation (2011)
-
Allogeneic stem cell transplantation in children with acute lymphoblastic leukemia after isolated central nervous system relapse: our experiences and review of the literature
Bone Marrow Transplantation (2006)
-
Autologous stem cell transplantation in hematological malignancies
Springer Seminars in Immunopathology (2004)
-
Autologous transplantation of CD133 selected hematopoietic progenitor cells in a pediatric patient with relapsed leukemia
Bone Marrow Transplantation (2002)