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Consolidation therapy with autologous stem cell transplantation in plasma cell leukemia after VAD, high-dose cyclophosphamide and EDAP courses: a report of three cases and a review of the literature

Bone Marrow Transplantation volume 20, pages 901–904 (1997)Cite this article

Abstract

Plasma cell leukemia (PCL) is a rare lymphoproliferative disorder characterized by a malignant proliferation of plasma cells in blood and bone marrow. Treatment of primary PCL has been mostly disappointing. Three patients with primary PCL are described who received high-dose melphalan with autologous PBSC support after vincristine, doxorubicine and dexamethasone (VAD), high-dose cyclophosphamide, and etoposide, cisplatinum, dexamethasone and cytosine arabinoside (EDAP) courses. All patients were in CR post-transplantation. One patient relapsed after 3 months; the other patients are still in CR, after 14 and 26 months, respectively. These results in conjunction with data from the literature suggest that intensive chemotherapy for PCL is promising.

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Authors and Affiliations

  1. Department of Hematology, University Hospital Groningen, The Netherlands

    S Hovenga, JThM de Wolf & E Vellenga

  2. Department of Immunochemistry, University Hospital Groningen, The Netherlands

    H Klip

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  1. S Hovenga
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  2. JThM de Wolf
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  3. H Klip
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  4. E Vellenga
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Hovenga, S., de Wolf, J., Klip, H. et al. Consolidation therapy with autologous stem cell transplantation in plasma cell leukemia after VAD, high-dose cyclophosphamide and EDAP courses: a report of three cases and a review of the literature. Bone Marrow Transplant 20, 901–904 (1997). https://doi.org/10.1038/sj.bmt.1700982

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  • DOI: https://doi.org/10.1038/sj.bmt.1700982

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