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Malaria infection after allogeneic bone marrow transplantation in a child with thalassemia

Bone Marrow Transplantation volume 19, pages 1259–1260 (1997)Cite this article

Abstract

A 12-year-old girl with β-thalassemia hemoglobin E disease received a marrow transplant from her HLA-identical elder brother in July 1995. She had previously been treated by repeated blood transfusions. Conditioning included busulfan 16 mg/kg for 2 days and cyclophosphamide 120 mg/kg for 2 days. Cyclosporine was used for graft-versus-host disease prophylaxis. Spiking fevers occurred on days 6 and 11. Plasmodium falciparum parasites, both trophozoites and gametocytes, were found on the peripheral blood smear. Quinine 30 mg/kg three times a day for 7 days followed by a single dose of mefloquine 25 mg/kg was given. The fever subsided within 2 days and parasitemia cleared in 4 days. After transplant, the girl autologously reconstituted and was followed-up over 15 months.

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Authors and Affiliations

  1. Blood Transfusion and Hematology Center, Hochiminh City,

    V-B Tran & V-B Tran

  2. Department of Hematology, Hochiminh Medical School, Vietnam

    V-B Tran & V-B Tran

  3. Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan

    K-H Lin

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  1. V-B Tran
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  2. V-B Tran
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  3. K-H Lin
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Tran, VB., Tran, VB. & Lin, KH. Malaria infection after allogeneic bone marrow transplantation in a child with thalassemia. Bone Marrow Transplant 19, 1259–1260 (1997). https://doi.org/10.1038/sj.bmt.1700822

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  • DOI: https://doi.org/10.1038/sj.bmt.1700822

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