Abstract
RECENTLY1,2 we reported the actions of serum vasoconstrictor, partially purified by the method of M. M. Rapport3. The evidence at the time strongly indicated that all the pharmacological actions which were shown by our preparations were due to a single substance—the vasoconstrictor of serum—and supported Rapport's finding that the active substance was an indolalkylamine. Having, through the kindness of Dr. Rapport, obtained a few milligrams of 5-hydroxytryptamine synthesized by a group at the Upjohn Chemical Co., we have been able to confirm that this product has all the actions which we described for the partially purified material.
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References
Reid, G., and Rand, M., Aust. J. Exp. Biol., 29, 401 (1951).
Rand, M., and Reid, G., Aust. J. Exp. Biol., 30 (1952).
Rapport, M. M., Green, A. A., and Page, I. H., J. Biol. Chem., 174, 735 (1948).
Reid, G., Med. J. Aust., 2, 244 (1943).
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REID, G., RAND, M. Pharmacological Actions of Synthetic 5-Hydroxytryptamine (Serotonin, Thrombocytin). Nature 169, 801–802 (1952). https://doi.org/10.1038/169801a0
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DOI: https://doi.org/10.1038/169801a0
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