Abstract
AMELLIN, which has been found to have beneficial effects in clinical and experimental diabetes1–3, has recently been observed by one of us (S. P.) in a preliminary investigation on the depancreatized dog to have the property of completely preventing the fatty degeneration of the liver. It was reported earlier by Nath and Brahmachari4 that amellin (given orally) in the daily dose of 25 mgm. per kgm. can cause considerable desaturation of the liver fat, which according to Schoenheimer and Rittenberg5 is an indication of increased fat metabolism. Nath and Chakrabarti3 have also recorded the prevention of tumorous growth in the livers of the animals with acetoacetate-induced diabetes, by simultaneous injection of amellin in a dose of 10 mgm. per kgm. Studies were therefore undertaken to observe the lipotropic effect of amellin in experimental animals.
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Nath, M. C., and Chakrabarti, C. H., Proc. Soc. Exp. Biol. and Med., 75, 326 (1950).
Nath, M. C., and Brahmachari, H. D., Ann. Biochem. and Exp. Med., 9, 13 (1949).
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Montini, T., and Pontremoli, S., Boll. Soc. Ital. Biol. Sper., 26, 8 (1950).
Nath, M. C., and Hatwalne, V. G. (unpublished observation).
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NATH, M., GADGIL, J. & PONTREMOLI, S. Effect of Amellin in the Prevention of Fatty Infiltration in the Liver. Nature 169, 711 (1952). https://doi.org/10.1038/169711a0
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DOI: https://doi.org/10.1038/169711a0
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