Abstract
LEUKÆMIC cells of the mouse develop resistance to various analogues of folic acid1,2. The variant cells in certain cases depend upon the 4-amino-substituted folic antagonists for optimal growth3. The changes are found to be stable, irreversible and heritable4, and occur generally among many transplantable leukæmias5.
This is a preview of subscription content, access via your institution
Access options
Similar content being viewed by others
References
Burchenal, J. H., Robinson, E., Johnston, S. F., and Kushida, M. N., Science, 111, 116 (1950).
Law, L. W., and Boyle, P. J., Proc. Soc. Exp. Biol. and Med., 74, 599 (1950).
Law, L. W., Proc. Soc. Exp. Biol. and Med., 77, 340 (1951).
Law, L. W., J. Nat. Cancer Inst., 11, 849 (1950).
Unpublished observations.
Luria, S. E., and Delbrück, M., Genetics, 28, 491 (1943).
Newcombe, H. B., Nature, 164, 150 (1949).
Newcombe, H. B., and Nyholm, M. H., Genetics, 35, 603 (1950).
Demerec, M., Proc. U.S. Nat. Acad. Sci., 31. 16 (1945).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
LAW, L. Origin of the Resistance of Leukæmic Cells to Folic Acid Antagonists. Nature 169, 628–629 (1952). https://doi.org/10.1038/169628a0
Issue Date:
DOI: https://doi.org/10.1038/169628a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.