Letter | Published:

Action of some Water-soluble Poly-α-Amino-Acids on Bacteria

Naturevolume 169pages10951096 (1952) | Download Citation



SOME of the antibiotics formed by fungi and bacteria have been found to consist of α-amino-acids linked by peptide bonds1. The recent work of Bloom, Watson, Cromartie and their associates2 showed that even the cells of higher animals may, in certain circumstances, for example, in infection with anthrax, excrete antibacterial substances of peptide nature. These facts encouraged us to study the biological properties of some synthetic water-soluble poly-α-amino-acids, which were synthesized in this laboratory3.

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  1. 1

    Synge, R. L. M., Quart. Rev., 3, 245 (1949).

  2. 2

    Bloom, W. L., Watson, D. W., Cromartie, W. J., and Freed, M., J. Infect. Dis., 80, 41 (1947). Bloom, W. L., and Blake, F. G., ibid., 83, 116 (1948). Watson, D. W., Cromartie, W. J., Bloom, W. L., Kegeles, G., and Heckly, R. J., ibid., 80, 28 (1947). Watson, D. W., Cromartie, W. J., Bloom, W. L., Heckly, R. J., McGhee, W. J., and Weissman, N., ibid., 80, 121 (1947).

  3. 3

    Katchalski, E., “Advances in Protein Chemistry”, 6, 123 (1951).

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  1. Weizmann Institute of Science, Rehovoth, Israel

    •  & B. E. VOLCANI


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