Letter | Published:

Release of Histamine from Rat Diaphragm by Cobra Venom

Nature volume 169, pages 10641065 (21 June 1952) | Download Citation

Subjects

Abstract

SEVERAL substances like strychnine, adrenaline and curare alkaloids are known to set free histamine from skeletal muscle. The release of histamine from rat diaphragm by ammonia1 and B-tubo-curarine chloride2 has recently been reported. Feldberg and Kellaway3 have shown that snake poisons liberate histamine from the perfused lungs of guinea pigs and cats. The experiments described here demonstrate that cobra (Naia naia) venom is a potent liberator of histamine from striated muscle of the rat.

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References

  1. 1.

    , Nature, 164, 24 (1949).

  2. 2.

    and , J. Physiol., 109, 448 (1949).

  3. 3.

    , and , J. Physiol., 90, 257 (1937).

  4. 4.

    , and , Ind. Med. Gaz., 74, 422 (1939).

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Author information

Affiliations

  1. Haffkine Institute, Bombay 12. Jan. 7.

    • N. K. DUTTA
    •  & K. G. A. NARAYANAN

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DOI

https://doi.org/10.1038/1691064b0

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