Letter | Published:

Release of Histamine from Rat Diaphragm by Cobra Venom

Nature volume 169, pages 10641065 (21 June 1952) | Download Citation



SEVERAL substances like strychnine, adrenaline and curare alkaloids are known to set free histamine from skeletal muscle. The release of histamine from rat diaphragm by ammonia1 and B-tubo-curarine chloride2 has recently been reported. Feldberg and Kellaway3 have shown that snake poisons liberate histamine from the perfused lungs of guinea pigs and cats. The experiments described here demonstrate that cobra (Naia naia) venom is a potent liberator of histamine from striated muscle of the rat.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    , Nature, 164, 24 (1949).

  2. 2.

    and , J. Physiol., 109, 448 (1949).

  3. 3.

    , and , J. Physiol., 90, 257 (1937).

  4. 4.

    , and , Ind. Med. Gaz., 74, 422 (1939).

Download references

Author information


  1. Haffkine Institute, Bombay 12. Jan. 7.

    • N. K. DUTTA
    •  & K. G. A. NARAYANAN


  1. Search for N. K. DUTTA in:

  2. Search for K. G. A. NARAYANAN in:

About this article

Publication history





By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.