Letter | Published:

Crystal Structures of Two Para-substituted Phenylpropionic Acids

Nature volume 169, page 1008 (14 June 1952) | Download Citation

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Abstract

β-PHENYLPROPIONIC acid is of particular interest as an inhibitor in the carboxypeptidase system1, in addition to its general interest in biology. One of us2 has shown that the unsubstituted acid is not amenable to X-ray analysis, having eight molecules in a monoclinic primitive cell. We have therefore studied the para-substituted chlorine and bromine compounds. They are isomorphous, with cell data as follows: in each case with four molecules per unit cell. Weissenberg multiple-film techniques were used in visual evaluation of the reflexion intensities, and the precession camera was used in determining the cell dimensions and in checking the orientation adopted. The [010] projections are well resolved for both these substances and are quite similar. That for the chlorine compound is illustrated in the accompanying diagram. The [001] projections are less well resolved.

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References

  1. 1.

    For example, see , and , Cold Spring Harbor Symp. Quant. Biol., 14, 168 (1950).

  2. 2.

    , Phil. Mag., 3, 1252 (1927).

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Author information

Affiliations

  1. Institute for Cancer Research and Lankenau Hospital Research Institute, Philadelphia 11, Pennsylvania. April 1.

    • A. L. PATTERSON
    •  & JOAN R. CLARK

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DOI

https://doi.org/10.1038/1691008a0

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