Identification of the Free Carboxyl Groups in Peptides

Abstract

THE Schlack and Kumpf procedure1 for identifying the amino-acids which provide terminal carboxyl groups in peptides has been made the basis of a micro method which works well with simple peptides and may be of use in studying the free α-carboxyl groups in proteins. In the case of glycylleucine and glycylvaline, the method has been used successfully, although preliminary experiments with insulin and wool keratin have indicated that some modification of the procedure may be necessary before it can be used with proteins.

References

  1. 1

    Schlack, P., and Kumpf, W., Z. physiol. Chem., 154, 125 (1926).

  2. 2

    Edman, P. (private communication, 1949).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

TIBBS, J. Identification of the Free Carboxyl Groups in Peptides. Nature 168, 910 (1951). https://doi.org/10.1038/168910a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.