Abstract
THE first snake-venom prepared in the pure crystalline form was crotoxin from Crotalus terr. terr. as described in 1938; at that time only its cystine and methionine contents were quantitatively determined1. This protein, with a molecular weight of 30,0002, proved to be homogeneous3 in the ultra-centrifuge2 as well as by electrophoresis4.
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References
Slotta, K. H., and Fraenkel-Conrat, H. L., Nature, 142, 213 (1938).
Gralén, N., and Svedberg, Th., Biochem. J., 32, 1375 (1938).
Slotta, K. H., and Fraenkel-Conrat, H. L., Nature, 144, 290 (1939).
Choh Hao Li and Fraenkel-Conrat, H. L., J. Amer. Chem. Soc., 64, 1586 (1942).
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Hasson, A., and Gonçalves, J. M., Ciência e Cultura, 2, 54 (1950).
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SLOTTA, K., PRIMOSIGH, J. Amino-acid Composition of Crotoxin. Nature 168, 696–697 (1951). https://doi.org/10.1038/168696a0
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DOI: https://doi.org/10.1038/168696a0
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