Letter | Published:

Identification of a Heparin as a Main Component of the ‘Third Factor’ involved in the Virulence-enhancing Action of Hog Gastric Mucin

Naturevolume 168pages563564 (1951) | Download Citation

Subjects

Abstract

PREVIOUS work1–4 has shown that the virulence-enhancing action of hog gastric mucin is due to a synergic action between two non-specific factors (a viscous medium and particulate residue), and a more specific soluble third factor. Partial purification of the latter3 yielded a heterogeneous product which was predominantly peptide in nature, but which contained 5–10 per cent of carbohydrate residues. Further purification, using a revised assay4 in which the two non-specific factors are maintained constant, has shown that the carbohydrate moiety is responsible for the activity.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Smith, H., Biochem. J., 46, 352 (1950).

  2. 2

    Smith, H., Biochem. J., 46, 356 (1950).

  3. 3

    Smith, H., Biochem. J., 48, 441 (1951).

  4. 4

    Smith, H., Stanley, J. L., and Harris-Smith, P. W., Biochem. J. (in the press).

  5. 5

    Dische, Z., J. Biol. Chem., 167, 189 (1947).

  6. 6

    Jorpes, J. E., and Gardell, S., J. Biol. Chem., 176, 267 (1948).

  7. 7

    Ecker, E. E., and Gross, P., J. Infect. Dis., 44, 250 (1929).

  8. 8

    Reinert, M., and Winterstein, A., Arch. intern. pharmaco-dynamie, 62, 47 (1939).

  9. 9

    Wolfrom, M. L., Weisblat, L. I., Karabinos, J. V., McNeely, W. H., and McLean, J., J. Amer. Chem. Soc., 65, 2077 (1943).

  10. 10

    Jorpes, J. E., Boström, H., and Mutt, V., J. Biol. Chem., 183, 607 (1950).

  11. 11

    Elson, L. A., and Morgan, W. T. J., Biochem. J., 27, 1824 (1933).

  12. 12

    Jorpes, E., Biochem. J., 29, 1817 (1935).

  13. 13

    Jorpes, E., Biochem. J., 36, 203 (1942).

Download references

Author information

Affiliations

  1. Microbiological Research Department, Porton, Wilts

    • H. SMITH

Authors

  1. Search for H. SMITH in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/168563a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.