Abstract
A NUMBER of workers have demonstrated the inhibition of growth in the rat and mouse1,2, bacteria3–5, and in the chick6–8 by means of folic acid antagonists. Seeger et al.5 have shown that 4-amino pteroyl glutamic acid is a powerful antagonist of folic acid by the Streptococcus fæcalis R. test, and its toxicity in mammals has been well established. Karnofsky et al.7 demonstrated quite conclusively that 4-amino pteroyl glutamic acid, as an analogue of folic acid, has the ability to inhibit growth in the chick, and the question arose as to whether this reaction could be found in a cold-blooded vertebrate as well. In this preliminary report, the growth inhibition of amphibian larvæ by 4-amino pteroyl glutamic acid is indicated, particularly in the growth phases in the middle and late larvæ. Studies on inhibition in early development, effects on embryo-genesis, and possible reversal effects are to be presented elsewhere at a later date.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Franklin, A. L., Stokstad, E. L. R., and Jukes, T. H., Proc. Soc. Exp. Biol. Med., 67, 398 (1948).
Philips, F. S., and Thiersch, J. B., J. Pharm. and Exp. Therap., 95, 303 (1949).
Franklin, A. L., Stokstad, E. L. R., Hoffman, C. E., Belt, M., and Jukes, T. H., J. Amer. Chem. Soc., 71, 3549 (1949).
Sauberlich, H. E., Fed. Proc., 8, 247 (1949).
Seeger, O. R., Smith, jun., J. M., and Hultquist, M. E., J. Amer. Chem. Soc., 69, 2567 (1947).
Franklin, A. L., Stokstad, E. L. R., and Jukes, T. H., Proc. Soc. Exp. Biol. Med., 65, 368 (1947).
Karnofsky, D. A., Patterson, P. A., and Ridgeway, L. P., Proc. Soc. Exp. Biol. Med., 71, 447 (1949).
Wagley, P. F., and Morgan, H. R., Bull. Johns Hopkins Hosp., 83, 275 (1948).
Shumway, W., Anat. Rec., 78, 139 (1940).
Velardo, J. T. (personal observation).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ROSENBAUM, R., VELARDO, J. Growth Inhibition in Amphibian Larvæ by 4-Amino Pteroyl Glutamic Acid (Aminopterin). Nature 168, 424–425 (1951). https://doi.org/10.1038/168424b0
Issue Date:
DOI: https://doi.org/10.1038/168424b0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.