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Sweating in Man from the Intradermal Injection of norAdrenaline


IT has been generally believed that sweating in man is produced in response to sympathetic nervous activity by the liberation at the termination of the post-ganglionic fibre supplying the sweat gland of acetylcholine1, the transmitter being different from that liberated by sympathetic fibres supplying other organs, which, until recently, was believed to be adrenaline, However, evidence has accumulated that there is an adrenergic component in sweating in man. Sweating is a prominent feature in patients with phæochromocytomata2, which were believed to secrete adrenaline. Spontaneous sweating in man is abolished by the adrenolytic agent ‘Dibenamine’3. The intradermal injection of adrenaline has been shown to produce sweating4.

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BARNETT, A. Sweating in Man from the Intradermal Injection of norAdrenaline. Nature 167, 482–483 (1951).

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