Letter | Published:

Statistical Planning in Experiments on the Isolated Rat Uterus

Naturevolume 166page117 (1950) | Download Citation



THE use of statistical methods for obtaining estimates of error in biological assays was demonstrated by Schild1 in a paper on the assay of histamine using guinea pig gut as test object. In 1943, Beauvillain2 used the rat uterus for assays of oxytocic activity in pituitary preparations, and recently Holton3 has applied Schild's methods to assays of posterior pituitary extract using the same preparation. Holton has shown that assays on the isolated rat uterus may be made more rapidly than on the isolated guinea pig uterus as prescribed in the British Pharmacopœia4, and the accuracy of her assays was greater.

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  1. 1

    Schild, H. O., J. Physiol., 101, 115 (1942).

  2. 2

    Beauvillain, A., C.R. Soc. Biol., Paris, 137, 284 (1943).

  3. 3

    Holton, P., Brit. J. Pharmacol., 3, 328 (1948).

  4. 4

    British Pharmacopœia”, 813 (London: Constable, 1948).

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  1. Pharmacology Laboratories, Pharmacy Department, University of Nottingham

    • J. G. FLETCHER


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