Abstract
FOLLOWING the pure hypothesis that macrocytic anæmias could be due to an anaphylactic blockage of the bone marrow, especially as regards erythropoiesis, it was supposed that folic acid, the action of which in these anæmias has been of some help, might have an anti-anaphylactic action. Experiments were therefore performed which showed folic acid to possess a protective action on the anaphylaxis of the guinea pigs1. I thought it would be interesting to see whether such an anti-anaphylactic action might be shown also by vitamin B12, which has turned out to be very effective, even in a very small dosage, in the treatment of pernicious and some other macrocytic anæmias2–4.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Traina, V., Nature, 163, 364 (1949).
Hall, B. E., and Campbell, D. C., Proc. Staff Meet., Mayo Clin., 23, 584 (1948).
Hall, B. E., and Campbell, D. C., Proc. Staff Meet., Mayo Clin., 23, 591 (1948).
Spies, T. D., Stone, R. E., Garcia Lopez, G., Milanes, F., Lopez Toca, R., and Aramburu, T., Lancet, ii, 519 (1948).
Berk, L., Denny Brown, D., Finland, M., and Castle, W. B., New Eng. J. Med., 239, 328 (1948).
Marcus, S., Proc. Soc. Exp. Biol. and Med., 66, 181 (1947).
Traina, V., and Alekdandrowicz, D., Nature, 163, 364 (1949).
Friedlander, F., Feinberg, S. M., and Feinberg, A. R., Proc. Soc. Exp. Biol. and Med., 62, 65 (1946).
Loew, E. R., and Kaiser, M. E., Proc. Soc. Exp. Biol. and Med., 58, 235 (1945).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
TRAINA, V. Vitamin B12 as an Anti-Anaphylactic. Nature 166, 78–79 (1950). https://doi.org/10.1038/166078b0
Issue Date:
DOI: https://doi.org/10.1038/166078b0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.