Abstract
YEAST1–4 and red blood cells5 contain enzyme systems which require coenzyme II and are capable of oxidizing glucose-6-phosphate to 6-phosphogluconic acid. The oxidation can also proceed further1,3,6, and evidence has been presented that in yeast stepwise C1- and C2-oxidation and decarboxylation may proceed via a pentose phosphoric ester; this was considered to be D-ribose-5-phosphate rather than D-arabinose-5-phosphate, which, although it has the configuration of D-glucose, is not attacked by yeast enzymes6. Further support for this view has recently been provided by the chromatographic identification of 2-ketogluconate and D-ribose-5-phosphate among the oxidation products of 6-phosphogluconic acid7.
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DICKENS, F., GLOCK, G. Direct Oxidation of Glucose-6-Phosphate by Animal Tissues. Nature 166, 33 (1950). https://doi.org/10.1038/166033a0
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DOI: https://doi.org/10.1038/166033a0
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