Letter | Published:

Direct Oxidation of Glucose-6-Phosphate by Animal Tissues

Nature volume 166, page 33 (01 July 1950) | Download Citation

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Abstract

YEAST1–4 and red blood cells5 contain enzyme systems which require coenzyme II and are capable of oxidizing glucose-6-phosphate to 6-phosphogluconic acid. The oxidation can also proceed further1,3,6, and evidence has been presented that in yeast stepwise C1- and C2-oxidation and decarboxylation may proceed via a pentose phosphoric ester; this was considered to be D-ribose-5-phosphate rather than D-arabinose-5-phosphate, which, although it has the configuration of D-glucose, is not attacked by yeast enzymes6. Further support for this view has recently been provided by the chromatographic identification of 2-ketogluconate and D-ribose-5-phosphate among the oxidation products of 6-phosphogluconic acid7.

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Affiliations

  1. Courtauld Institute of Biochemistry, Middlesex Hospital Medical School, London, W.1. May 5.

    • F. DICKENS
    •  & GERTRUDE E. GLOCK

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DOI

https://doi.org/10.1038/166033a0

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