Abstract
ALTHOUGH the structure of the strychnine molecule has now been fairly definitely established on chemical grounds the evidence of X-ray crystallography is of interest, especially as regards stereochemical details. The formula favoured by Robinson and Woodward1 was first confirmed by Bijvoet, Schoone and Bokhoven2, who examined the sulphate and selenate. We have completed a full analysis of strychnine hydrobromide, in which both three-dimensional Patterson and Fourier syntheses were employed. The chemical structure has been reliably verified, and moderately accurate representation of the molecule has been obtained.
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References
Robinson, et al., J. Chem. Soc., 903 (1946). Nature, 160, 18 (1947). Woodward, Brehm and Nelson, J. Amer. Chem. Soc., 69, 2250 (1947).
Bijvoet, Schoone and Bokhoven, Kon. Ned. Akad. Wet., 50, No 8, 51, No. 8, 52, No. 2 (1947–49).
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ROBERTSON, J., BEEVERS, C. Crystal Structure of Strychnine Hydrobromide. Nature 165, 690–691 (1950). https://doi.org/10.1038/165690a0
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DOI: https://doi.org/10.1038/165690a0
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