Chemical Nature of Nuclear Sap


IN the past few years there has been considerable argument about the disposition within cell nuclei of the chemical substances, predominantly proteins, histones and nucleic acids, which can be extracted from isolated nuclei by chemical procedures1–4. It is the purpose of the present communication to describe two preliminary experiments which provide information as to the chemical constitution of nuclear sap.

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    Stedman, E., and Stedman, E., Nature, 152, 267 (1943).

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    Callan, H. G., Nature, 152, 503 (1943).

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    Stedman, E., and Stedman, E., Nature, 152, 503 (1943).

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    Caspersson, T., Nature, 153, 499 (1944).

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    Davidson, J. N., and Lawrie, R. A., Biochem. J. Proc., 43, xxiv (1948).

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    Markham, R., and Smith, J. D., Nature, 163, 250 (1949).

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BROWN, G., CALLAN, H. & LEAF, G. Chemical Nature of Nuclear Sap. Nature 165, 600–601 (1950).

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