Distribution of Protein in the Tissues of Rats Treated with Anterior-Pituitary Growth-Hormone

Abstract

RATS treated with growth-promoting anterior-pituitary extracts¹ or with purified pituitary growth-hormone² gain more body-weight than pair-fed control animals. In experiments with rats, cats and dogs fed a constant amount of food throughout the experiment, Young³ found that diabetogenic growth-promoting anterior-pituitary extract induced a substantial rise in body-weight even when, as with the dog and the cat, a severely diabetic condition simultaneously developed. In all these investigations evidence was adduced to show that the rise in body-weight in the pituitary-treated animals resulted mainly from a deposition of protein-containing tissue. The present experiments were designed to indicate the site of the protein deposited in the bodies of pair-fed rats treated with purified pituitary growth-hormone.