Mechanism of Glyceraldehyde Inhibition of Glycolysis


THE effect of low concentrations of monomeric glyceraldehyde in inhibiting lactic acid formation in tissues using glucose but not in those using glycogen has been the subject of much experimentation and discussion. Stickland1 used dialysed muscle extract, reinforced with yeast hexokinase, and studied both substrates with this system. 0.01–0.001 M glyceraldehyde caused 80–90 per cent inhibition with glucose but had little or no effect with glycogen. Stickland found (private communication) by special tests that glyceraldehyde was not inhibiting hexokinase in this system.

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NEEDHAM, D., SIMINOVITCH, L. & RAPKINE, S. Mechanism of Glyceraldehyde Inhibition of Glycolysis. Nature 165, 521 (1950).

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