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Amino-acid Composition of Bence–Jones Protein


OUR knowledge of the amino-acid composition of Bence–Jones protein is still incomplete. Recently, Dent1 has analysed a specimen of Bence–Jones protein, using paper partition chromatography, with regard to its amino-acid composition. He found that the specimen contained all the common amino-acids except methionine and hydroxyproline. Dent's findings were at variance with those of Devine2, who found methionine present in amount 0.58 per cent.


  1. 1

    Dent, C. E., and Rose, C. A., Proc. Biochem. Soc. (December 1948).

  2. 2

    Devine, J., Biochem. J., 35, 433 (1941).

    CAS  Article  Google Scholar 

  3. 3

    Consden, R., Gordon, A. H., and Martin, A. J. P., Biochem. J., 38, 224 (1944).

    CAS  Article  Google Scholar 

  4. 4

    Feigl, F., "Quantitative Analysis by Spot Tests", 354 (Blaevier, New York, 1947).

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  5. 5

    Waldenström, J., Acta Med. Scand., 117, 215 (1944).

    Google Scholar 

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PAPASTAMATIS, S., KENCH, J. & WILKINSON, J. Amino-acid Composition of Bence–Jones Protein. Nature 164, 961 (1949).

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