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Inositol and Phosphorylation of Liver Lipids

Nature volume 164, pages 621–622 (1949)Cite this article

Abstract

THE lipotropic actions in the liver of inositol and choline are well established. The action of choline on liver lipids has been related to phospholipid metabolism ; there is no explanation of the lipotropic effect of inositol, although Handler1 has suggested that inositol may act as a catalyst in phosphorylation. When choline and inositol are administered to rats on certain diets, the reduction in concentration of liver lipid is greater than if either is given singly1,2. This might be due to an effect of inositol on the choline-containing phospholipid of the liver, or to the existence of an alternative path of fat metabolism involving inositol. We have investigated the effect of injected inositol on liver phospholipid synthesis.

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Authors and Affiliations

  1. Human Nutrition Research Unit, Medical Research Council, National Hospital, Queen Square, London, W.C.1

    M. BLEWETT, I. G. CAMPBELL & JUNE OLLEY

Authors
  1. M. BLEWETT
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  2. I. G. CAMPBELL
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  3. JUNE OLLEY
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BLEWETT, M., CAMPBELL, I. & OLLEY, J. Inositol and Phosphorylation of Liver Lipids. Nature 164, 621–622 (1949). https://doi.org/10.1038/164621a0

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