Letter | Published:

Antibacterial Action of Curcumin and Related Compounds

Nature volume 164, pages 456457 (10 September 1949) | Download Citation



INVESTIGATIONS by A. R. Todd1, H. Rinderknecht2, W. B. Geiger3 and others have shown that many unsaturated ketones with the grouping —C = C—CO—, also present in a number of naturally occurring antibiotics, possess antibacterial action. In our studies on unsaturated ketones, we found that chalkone, flavanone, flavone and some of their derivatives, for example, buteine (2,4,3',4'-tetrahydroxychalkone). a substance of vegetable origin, showed a marked inhibition of the growth of Staph. aureus. Also extracts of plants containing flavanones, flavones or flavonoles were found to be bacteriostatic4. Furthermore, we have prepared a number of synthetic chalkones of which some compounds suppressed the growth at high dilutions.

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  1. Laboratory of R. Pfleger, University of Erlangen. March 15.

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