Influence of Desoxycorticosterone on Glycogen Formation and Glucose Uptake of Isolated Muscle

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Abstract

ISOLATED diaphragm muscle of rats produces glycogen from glucose especially in the presence of insulin in oxygenated Ringer's solution. This is inhibited by the addition of small doses of desoxycorticosterone1. If the muscle works in response to rhythmic stimulation for two hours, glycogen is newly formed and is broken down again. This is also inhibited by desoxycorticosterone2. The action of other steroid hormones was also studied. They had either equal effect (progesterone, testosterone) or none (corticosterone, etc.)3.

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References

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    Verzár, F., and Wenner, V., Biochem. J., 42, 35 (1948).

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    Mentha, J., and Voegtli, W., Helv. Physiol. Acta, 5, C 43 (1947); 6, 853 (1948).

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    Verzár, F., and Wenner, V., Biochem. J., 42, 48 (1948).

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    Krahl, M. E., and Park, C. R., J. Biol. Chem., 174, 939 (1948). Perlmutter, M., and Creep, R. O., J. Bio. Chem., 174, 915 (1948).

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    Conway, E. J., "Microdiffusion Analysis and Volumetric Error", 85 (London, 1947).

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LEUPIN, E., VERZÁR, F. Influence of Desoxycorticosterone on Glycogen Formation and Glucose Uptake of Isolated Muscle. Nature 163, 836 (1949) doi:10.1038/163836a0

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