Metabolism of the Œstrogen Triphenyl-bromoethylene

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THIS work was undertaken to investigate the metabolism in mice of the synthetic œstrogen triphenyl-bromoethylene, using radioactive tracer methods. It was felt important to study further the possibility of a selective absorption leading to the concentration of radioactivity in certain organs. We have been unable to confirm the finding of Daudel and his colleagues that a selective absorption occurs in certain organs, notably the ovaries of mice1. Nevertheless, other information of interest was obtained on the metabolism of the drug.

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  1. 1

    Daudel, Berger, Buu-Hoï, and Lacassagne, Experientia, 2/3, 1 (1946).

  2. 2

    Veall, Brit. J. Rad., 21, 347 (1948).

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PATERSON, E., GILBERT, C., GALLAGHER, U. et al. Metabolism of the Œstrogen Triphenyl-bromoethylene. Nature 163, 801–802 (1949) doi:10.1038/163801a0

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