Abstract
IT was shown by Albert and Goldacre1 that an amino group substituted in a 'resonant position' of a six-membered aromatic heterocyclic base results in a compound of enhanced basic strength. This is attributed to the replacement of a dipolar resonant form by a more stable homopolar resonant form.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Albert, A., and Goldacre, R., Nature, 153, 467 (1944).
Albert, A., and Goldacre, R., J. Chem. Soc., 706 (1946).
Albert, A., Goldacre, R., and Phillips, J., J. Chem. Soc. (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GORE, P., PHILLIPS, J. Base-Strengthening Effect of Resonant Amino Groups in some Heterocyclic Bases. Nature 163, 690–691 (1949). https://doi.org/10.1038/163690a0
Issue Date:
DOI: https://doi.org/10.1038/163690a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.