Abstract
IT is commonly stated that the nodes originally described by Ranvier1, which are so characteristic a feature of peripheral nerve fibres, do not occur within the central nervous system. However, Ramón y Cajal, in his descriptions of those penetrating researches which have distinguished him as one of the foremost histologists of all time, refers repeatedly to étranglements or nodes on nerve fibres within the brain and spinal cord, and these are beautifully illustrated in some of his publications2,3. In spite of these observations, the absence of nodes in the central nervous system has often been assumed by some contemporary neurohistologists4,5 and in many standard text-books of histology and neurology.
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References
Ranvier, L., "Leçons sur l'histologie du système nerveux" (Paris, 1878).
Ramón y Cajal, S., "Histologie du Système Nerveux de l'Homme et des Vertebrés" (Paris, 1911), see Fig. 240.
Ramón y Cajal, S., "Degeneration and Regeneration of the Nervous System" (Oxford, 1928). see Fig. 185.
Young, J. Z., in "Essays on Growth and Form", edit, by Le Gros Clark and Medawar (Oxford, 1945).
Lorente de Nó, R., Stud. Rockefeller Inst. Med. Res., 132 (1947).
Feindel, W. H., Allison, A. C., and Weddell, G., [J. Neural. Neurosurg. and Psychiat., 11, 227 (1948)].
Zimmermann, K. W. (personal communication from Prof. Hintzsche).
Huxley, A. F., and Staempfli, R. (personal communication).
Tasaki, I., and Mizuguchi, K., J. Neurophysiol., 11, 295 (1948).
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ALLISON, A., FEINDEL, W. Nodes in the Central Nervous System. Nature 163, 449–450 (1949). https://doi.org/10.1038/163449b0
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DOI: https://doi.org/10.1038/163449b0
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