Abstract
THE theory that tissue damage in silicosis is caused by silicic acid formed by solvent action of the plasma on inhaled particles stimulated the study of the solubility of airborne siliceous dusts and of the materials which give rise to them. The investigation of the solubility of mineral silicates is complicated by their peculiar properties. When a powdered siiliceous mineral is shaken with water, the solution may contain particles which range from large colloidal particles to simple ions ; and different workers have determined the solute gravimetrically aftejr filtration1, gravimetrically after ultracentrifugmg2 or colorimetrically as the silicomolybdate complex which is formed both with simple and with more complex colloidal silicic a'cids. King and McGeorge3 consider that the colorimetric method is most likely to give figures representing physiologically active 'solubb silica'.
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References
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King, E. J., and McGeorge, M., Biochem. J., 32, 417 (1938).
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King, E. J., "Chronic Pulmonary Disease in South Wales Coal Miners, III", Med. Res. Counc. Spec. Rep. 250, p. 87 (1945).
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HOLT, P., BRISCOE, H. Solubility of Industrial Siliceous Dusts. Nature 163, 334–336 (1949). https://doi.org/10.1038/163334a0
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DOI: https://doi.org/10.1038/163334a0
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