Abstract
SODIUM thiosulphate has recently been recommended as a substance suitable for use in measuring the glomerular filtration-rate (G.F.R.) in the kidney. Its concentration in blood and urine is easily and reliably measured, it is neither re-absorbed nor secreted by the tubule cells in man1 or dog2,3, and is stated, to be non-toxic. In the cat it behaves very differently. It is actively secreted, that is, its clearance is higher than that of creatinine, which is a measure of the glomerular filtration-rate, and its clearance rises with falling concentration in the plasma, as can be seen in Fig. 1 This finding confirms the recent suggestion of Bing and Effersøe4.
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References
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Bing, J., and Effers e, P., Acta physiol. Scand., 15, 231 (1948).
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EGGLETON, M., HABIB, Y. Action of Thiosulphate on the Kidney of the Cat. Nature 163, 1000–1001 (1949). https://doi.org/10.1038/1631000a0
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DOI: https://doi.org/10.1038/1631000a0
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