Abstract
IT has been suggested1 that one of the biological roles of substances having so-called ‘vitamin P' action is their ability to protect epinephrine (or syrnpathin) from destruction in the body by combining with copper. This is believed to result in enhanced tone and diminished permeability of the capillaries, with a subsequent amelioration of the hæmorrhagic diatheses for which ‘vitamin P' has been claimed to be effective2. Many substances, ranging from such simple ones as catechol and pyrogallol3 to complex glycosides such as rutin1'4, have been reported as potentiating epinephrinemediated effects on isolated organs and in intact animals. An examination of the structure of those substances which have been reported to be effective in decreasing capillary fragility or permeability suggests that there may be no common mechanism of action of these substances.
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CLARK, W., GEISSMAN, T. Potentiation of Epinephrine Effects by Flavonoid Compounds. Nature 163, 36–37 (1949). https://doi.org/10.1038/163036a0
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DOI: https://doi.org/10.1038/163036a0
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