A New Ketone Synthesis

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THE reaction between substituted malonic esters and acid chlorides has been investigated on a number of occasions in the past1, and has been found to give the corresponding acylmalonic esters in high yield according to the following reaction :

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  1. 1

    Lang, Ber., 20, 1326. Michael, Amer. Chem. J., 14, 510.

  2. 2

    Robinson and Robinson, J. Chem. Soc., 127, 175 (1925).

  3. 3

    Walker and Hauser, J. Amer. Chem. Soc., 68, 1386 (1946).

  4. 4

    Bowman, unpublished results.

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BOWMAN, R. A New Ketone Synthesis. Nature 162, 111 (1948) doi:10.1038/162111a0

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