Abstract
IT has previously been reported that the xanthine oxidase content of mouse brain is markedly increased during infection with yellow fever and other viruses1,2, and evidence was adduced which suggested that this rise of enzyme activity was not fortuitous but was causally related to the growth of virus in the tissue. The possibility of the virus particles themselves having xanthine oxidase activity was excluded by the demonstrable lack of parallelism between enzyme activity and the amount of virus in the brain. Recent work reported here shows that the extra enzyme is not obtained from other parts of the body, and demonstrates that synthesis of xanthine oxidase takes place during virus infection.
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References
Bauer, D. J., Nature, 159, 438 (1947).
Bauer, D. J., Brit. J. Exp. Path., 28, 440 (1947).
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BAUER, D. Association of Xanthine Oxidase with Virus Multiplication. Nature 161, 852 (1948). https://doi.org/10.1038/161852a0
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DOI: https://doi.org/10.1038/161852a0
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