Abstract
SPIES et al.1 have reported the value of 5-methyluracil (thymine) in the treatment of pernicious anæmia. Jacobson and Williams2 have suggested the use of splenectomized rabbits for the assessment of anti-anæmic factors, and Bavin and Middleton3 have shown that thymine causes a reticulocytosis when injected into such splenectomized rabbits. We have used a similar method for the study of the hæmopoietic activity of various thymine derivatives.
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References
Spies, T. D., Frommeyer, W. B., Vilter, C. F., and English, A., Blood, 1, 185 (1944).
Jacobson, W., and Williams, S. M., J. Path. Bact., 57, 423 (1945).
Bavin, E. M., and Middleton, T. R., Nature, 158, 627 (1946).
Astwood, E. B., J. Pharmacol, 78, 79 (1943).
St. Johnston, C. R., Lancet, ii, 42 (1944).
Williams, R. H., Chute, H. M., Anglem, T. J., and Kenney, F. R., J. Clin. Endocrinol., 6, 23 (1946).
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CULLUMBINE, H., SIMPSON, M. Thio-thymine (2-Thio-5-Methyl-Uracil). Nature 159, 680 (1947). https://doi.org/10.1038/159680a0
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DOI: https://doi.org/10.1038/159680a0
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