Letter | Published:

Mitotic Disturbances Induced in Yeast by Chemicals, and their Significance for the Interpretation of the Normal Chromosome Conditions of Yeast

Nature volume 158, page 626 (02 November 1946) | Download Citation



THE camphor reaction of yeast, described by Bauch1, was interpreted by me2 as a narcosis affecting the normal growth of the yeast cell. Instead of budding normally, the yeast, under the influence of many chemicals of the same type as the narcotics, grows out into associations of cells, which show an irregular, tube-like, bottle-shaped or vesicular form. Their cell volume is often enlarged. In 1938 and 1939, Segal3 induced this reaction by treatment with the higher aliphatic alcohols and fusel oil. The so-called involution forms of yeast, often observed in ageing cultures in connexion with the autolysis, seems to be a phenomenon of the same nature, the yeast cells narcotizing themselves with their own metabolic products.

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    Naturwiss., 29 (1941).

  2. 2.

    Hereditas, 30 (1944).

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    Microbiologija, 7 (1938), 8 (1939).

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    Nature, 152 (1945).

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    Curr. Sci., 14 (1945).

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    Bull. Int. Acad. Polon., B, 61 (1937).

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    Cytologia, 11 (1941).

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    Mykologia, 37 (1945).

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  1. Cytogenetic Laboratory, Svalöf, Sweden. Sept. 18.



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