Abstract
THIOUREA and derivatives1–3 and sulphonamide compounds4,5 inhibit the formation of the catabolic hormone both in normal and in hyperactive thyroids. In a vain attempt to compensate for the lack of hormone, the gland undergoes hyperplasia, and hypothyroidism with hyperplastic goitre can result1,6. A few isolated results suggest that the possibility of the drugs also antagonizing the circulating hormone cannot be excluded7.
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PECZENIK, O. Action of Thyroxin and the Response of the Thyroid to Treatment with Sulpha Drugs. Nature 157, 771–772 (1946). https://doi.org/10.1038/157771b0
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DOI: https://doi.org/10.1038/157771b0
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