Concentration of Solutions of Salts of Penicillin


PENICILLIN as a chemotherapeutic agent is usually employed in the form of its sodium or calcium salt: a concentrated solution of one of these salts is used for parenteral injection or for local application. For the latter form of treatment penicillin in solid form is often used (usually the calcium salt). Owing to the instability of solutions of these salts of penicillin it is necessary to prepare and store the salts in the solid form and to dissolve in the appropriate volume of water or saline shortly before required.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Abraham, E. P., Chain, E., Fletcher, C. M., Gardner, A. D., Heatley, N. G., Jennings, M. A., and Florey, H. W., Lancet, ii, 177 (1941).

    CAS  Article  Google Scholar 

  2. 2

    Abraham, E. P., and Chain, E., Brit. J. Exp. Path., 23, 103 (1942).

    CAS  Google Scholar 

  3. 3

    Challinor, S. W., and MacNaughtan, J., J. Path, and J. Bact., 55, 441 (1943).

    CAS  Article  Google Scholar 

  4. 4

    McFarlane, A. S., Nature, 149, 439 (1942).

    ADS  CAS  Article  Google Scholar 

Download references

Author information



Rights and permissions

Reprints and Permissions

About this article

Cite this article

CHALLINOR, S., MACNAUGHTAN, J. Concentration of Solutions of Salts of Penicillin. Nature 156, 602–603 (1945).

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.