Influence of pH and Salts on the Solubility of Calcium Oxalate

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IT has been observed that ingestion of soluble oxalates aggravates the condition of oxaluria. Barrett1 has shown that oxalate absorption is reduced or even inhibited when milk or a soluble calcium salt is taken simultaneously. He explains this as an immobilization of the oxalate as calcium oxalate, which is almost insoluble at the pH obtaining in the intestine. Whether intestinal absorption of calcium oxalate is influenced by other ions has been little investigated. Fiske and Logan2 have noted the effect of magnesium, phosphate and sulphate on the solubility of calcium oxalate but have not presented quantitative data. We have investigated quantitatively the effects of acetate, borate and phosphate ions at various pH values on the solubility of calcium oxalate.

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  1. 1

    Barrett, I. F., Lancet, 213, 574 (1942).

  2. 2

    Fiske and Logan, J. Biol. Chem., 93, 211 (1931).

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