Prolongation of the Effect of Narcotics by Combination with Mucic Acid

Abstract

A SEARCH for improved methods of prolonging the effect of the injection of morphine and other narcotics resulted in the observation that, for a given dose of morphine, the period of narcosis can be considerably extended if the base is administered in the form of mucate instead of the usual salts such as tartrate, sulphate, etc. This prolongation of effect is also obtained with the mucic acid compounds of other physiologically active bases such as adrenaline and ergometrine.

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