Concurrence of Growth-promoting and Growth-inhibiting Factors in Extracts of Adult Rat Tissues


IN previous papers1 from this laboratory it was shown that saline extracts of adult tissues and organs have a marked growth promoting effect on cell colonies in vitro. Under given experimental conditions, the growth-promoting activity of certain adult tissue extracts is several times that of embryonic tissue extracts of the same concentration. Although most tissues and organs of the adult organism display the growth-promoting power, the activity of the extracts varies from organ to organ. It is particularly high in heart, brain and smooth muscle, and low in kidney, bone marrow and liver.

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  1. 1

    Doljanski, L., and Hoffman, R. S., C.R. Son. Biol., 130, 1264 (1939). Hoffman, R. S., and Doljanski, L., Growth, 3, 61 (1939). Hoffman, R. S., Tenenbaum, E., and Doljanski, L., Nature, 143, 764 (1939). Hoffman, R. S., Tenenbaum, E., and Doljanski, L., Growth, 4, 207 (1940).

  2. 2

    Doljanski, L., Hoffman, R. S., and Tenenbaum, E., Nature, 150, 23 (1942).

  3. 3

    Hoffman, R. S., Growth, 4, 361 (1940).

  4. 4

    Werner, H., and Doljanski, L., Nature, 150, 660 (1942).

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