Specific Protective Influence of Alanine in Differential Tissue Destruction by Hexenolactone (Parasorbic Acid)


MEDAWAR's differential 'mesoderm inhibitor', originally obtained from malt, ungerminated grain and oranges, has been closely reproduced through synthesis by Medawar, Robinson and Robinson1, who are not entirely certain whether their malt-distillate factor is optically active δ-hexenolactone or an allied substance. Because of structural similarity with panto-lactone, which combines with β-alanine to form pantothenic acid, synthetic dl-δ-Δαβ hexenolactone and its natural equivalent (probably parasorbic acid) were suspected of entering somehow into pantothenic acid metabolism, possibly by competition with pantolactone.

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  1. 1

    Medawar, P. B., Robinson, G. M., and Robinson, R., Nature, 151, 195 (1943).

  2. 2

    Kuhn, R., and Jerchel, D., Ber. Chem. Ges., 76 B, 413 (1943).

  3. 3

    Kuhn, R., Jerchel, D., Moewus, F., Moller, E. F., and Lettre, H., Naturwiss., 31, 468 (1943).

  4. 4

    Mendez, R., J. Pharmacol. and Exper. Therap., 81, 151 (1944).

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