Letter | Published:

Anti-sulphanilamide Activity of 2-Aminopyrimidine-5-carboxylic Acid

Nature volume 154, page 639 (18 November 1944) | Download Citation



THE observation of Woods1, that the anti-bacterial activity of sulphanilamide is inhibited by p-amino-benzoic acid, has been followed from time to time by observations recording a similar anti-sulphanilamide action for other compounds chemically unrelated to p-aminobenzoic acid. Thus Harris and Kohn2 have shown that dl-methionine antagonizes sulphanilamide action. Martin and Fisher3 have reported that adenine possesses anti-sulphanilamide activity in mice infected with streptococci comparable with that possessed by p-aminobenzoic acid. Snell and Mitchell4 found that adenine, guanine, xanthine and hypoxanthine, as well as dl-methionine, reversed sulphanilamide bacteriostasis of certain lactic acid bacteria, although the results were largely dependent on the particular organism and conditions employed. Anti-sulphanilamide action has also been demonstrated with urethane5.

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    , and , Arch. Biochem., I, 93 (1942).

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    , and , J. Amer. Chem. Soc., 64, 794 (1942)

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  1. Research Department, Imperial Chemical Industries, Ltd., (Dyestuffs Division), Manchester, 9. Sept. 19.

    • A. R. MARTIN
    • , F. L. ROSE
    •  & G. SWAIN


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