Letter | Published:

Anti-sulphanilamide Activity of 2-Aminopyrimidine-5-carboxylic Acid

Nature volume 154, page 639 (18 November 1944) | Download Citation

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Abstract

THE observation of Woods1, that the anti-bacterial activity of sulphanilamide is inhibited by p-amino-benzoic acid, has been followed from time to time by observations recording a similar anti-sulphanilamide action for other compounds chemically unrelated to p-aminobenzoic acid. Thus Harris and Kohn2 have shown that dl-methionine antagonizes sulphanilamide action. Martin and Fisher3 have reported that adenine possesses anti-sulphanilamide activity in mice infected with streptococci comparable with that possessed by p-aminobenzoic acid. Snell and Mitchell4 found that adenine, guanine, xanthine and hypoxanthine, as well as dl-methionine, reversed sulphanilamide bacteriostasis of certain lactic acid bacteria, although the results were largely dependent on the particular organism and conditions employed. Anti-sulphanilamide action has also been demonstrated with urethane5.

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References

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    , Brit. J. Expt. Path., 21, 74 (1940).

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Author information

Affiliations

  1. Research Department, Imperial Chemical Industries, Ltd., (Dyestuffs Division), Manchester, 9. Sept. 19.

    • A. R. MARTIN
    • , F. L. ROSE
    •  & G. SWAIN

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DOI

https://doi.org/10.1038/154639b0

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