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Reaction of Human Serum Albumin with Hæmatin and Hæm

Nature volume 154, pages 120–121 (1944)Cite this article

Abstract

IT was shown by Heilmeyer1 that the pigment in the blood serum of certain cases of pernicious anæmia accompanied by a severe "hæmatin jaundice" or "hæmatinæmia" differs from free alkaline hæmatin in that the absorption band is at about 620 mμ instead of at 610 mμ. As this pigment Was also obtained by Heilmeyer2 in vitro by adding hæmatin to blood serum, he concluded that "in serum the hæmatin combines with proteins which are only split off on adding an excess of concentrated alkali. Thus in serum we are concerned with the spectrum of a protein-hæmatin and not that of alkaline hæmatin".

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References

  1. Heilmeyer, L., Deutsch. Arch. Klin. Med., 173, 128 (1932).

    CAS  Google Scholar 

  2. Heilmeyer, L., "Medizinische apectrophotometrie" (Fischer, Jena, 1933): English translation: "Spectrophotometry in Medicine" (A. Hilger, 1943).

    Google Scholar 

  3. Fairley, N. H., and Bromfleld, R. J., Trans. Roy. Soc. Trop. Med. and Hyg., 28, 307 (1934); 31, 139 (1937); 31, 372 (1938).

    Article  CAS  Google Scholar 

  4. Fairley, N. H., Nature, 139, 588 (1937) and 142, 1156 (1938).

    Article  ADS  CAS  Google Scholar 

  5. Fairley, N. H., Brit. J. Exp. Path., 21, 231 (1940).

    CAS  Google Scholar 

  6. Foy, H., and Kondi, A., Trans. Roy. Soc. Trop. Med. and Hyg., 32, 49 (1938).

    Article  CAS  Google Scholar 

  7. Keilin, J., Biochem. J., 37, 281 (1943).

    Article  CAS  Google Scholar 

  8. Hill, R., and Holden, H. F., Biochem. J., 20, 1326 (1926).

    Article  CAS  Google Scholar 

  9. Haurowitz, F., and Waelsch, H., Hoppe-Seyl. Z., 182, 82 (1929).

    Article  Google Scholar 

  10. Gildemeister, H., Z. Exp. Med., 102, 58 (1937).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Molteno Institute, University of Cambridge,

    JOAN KEILIN

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  1. JOAN KEILIN
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KEILIN, J. Reaction of Human Serum Albumin with Hæmatin and Hæm. Nature 154, 120–121 (1944). https://doi.org/10.1038/154120a0

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