Abstract
IN a recent communication referring to the use of acid silver nitrate to demonstrate the intracellular localization of vitamin C, Barnett and Fisher1 state: "It is concluded that it is unjustifiable to infer the whereabouts of ascorbic acid within the cell from the site of silver precipitates obtained by the silver nitrate method". The bases for this statement are the results obtained on the staining of mixtures of gelatin and ascorbic acid and olive oil or ground glass with acid silver nitrate.
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References
Barnett, S. A., and Fisher, R. B., J. Exp. Biol., 20, 14 (1943).
Bourne, G. H., NATURE, 132, 850 (1933).
Bourne, G. H., Aust. J. Exp. Biol., 13, 239 (1935).
Leblond, C. P., "Recherches histochimiques sur la localisation et le cycle de la vitamins C dans l'organisme", Thèse méd. (Paris, 1934).
Giroud, A., "L'acide ascorbique dans la cellule et les tissus" (Protoplasma Monographien, Berlin, 1938).
Bourne, G. H., "Cytology and Cell Physiology" (Oxford, 1942).
Silver, Anat. Rec., 82, 507 (1942).
Hirsch, G. C., "Form and Stoffwechsel der Golgi-Körpen" (Protoplasma Monographien, Berlin).
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BOURNE, G. Intracellular Localization of Vitamin C. Nature 153, 254–255 (1944). https://doi.org/10.1038/153254a0
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DOI: https://doi.org/10.1038/153254a0
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