Abstract
ACCORDING to Doerr1, Sh. dysenteriœ fails to produce toxin in a synthetic medium, but regains its toxicity if transferred from the synthetic medium into alkaline broth. Braun and Cahn-Bronner2 showed that certain dysentery strains can utilize ammonium as source of nitrogen, and that they produce a weak toxin on media containing lactate as source of carbon, and ammonium as source of nitrogen. From a medium with this composition Wichmann3 produced a toxin with a minimal lethal dose of 1.0–2.0 c.c. on rabbits of about 1,000 gm. weight.
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References
Doerr, R., "Handbuch der Technik und Methodik der Immunitaetsforschung", edited by R. Kraus and C. Levaditi (G. Fischer, Jena, 1908), p. 1,150.
Braun, H., and Cahn-Bronner, C. E., Biochem. Z., 131, 3 (1922).
Wichmann, F. W., Arbeiten aus dem Staatsinstitut fuer experimentelle Therapie und dem Georg Speyer Hause zu Frankfurt a.M., 21, 362 (1928).
Gildemeister, E., and Grillo, J., Zentralbl. f. Bakt., I. Abt., Orig., 133, 201 (1934).
Takita, J., Kitasato Archiv. Exp. Med., 16, 174 (1939).
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OLITZKI, L., KOCH, P. Production of Potent Toxins by Shigella dysenteriae (Shiga) in a Synthetic Medium. Nature 151, 334 (1943). https://doi.org/10.1038/151334b0
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DOI: https://doi.org/10.1038/151334b0
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