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Retarding Effect of Ghost Formation on Absorption from Subcutaneously Implanted Tablets of Hexœstrol


IT has recently been reported1 that when tablets of synthetic œstrogens are implanted subcutaneously into bovines, the outer or 'cortical' layer of the tablets becomes infiltrated with a structure apparently composed of relatively insoluble protein. The formation of this structure, for which the name 'ghost' was proposed, should not be confused with the phenomenon of encapsulation of the tablet within a sac of fibrous or connective tissue, which was considered by Goist et al.2 to cause a considerable decrease in absorption from tablets implanted into humans. Whatever may be the effect of encapsulation, it was considered likely that ghost formation would retard absorption, and experimental evidence that this is so has now been obtained.

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  1. Folley, S. J., NATURE, 150, 403 (1942).

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  2. Geist, S. H., Walter, R. I., and Salmon, U. J., Proc. Soc. Exp. Biol., 43, 712 (1940).

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  3. Emmens, C. W., Endocrin., 28, 633 (1941).

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  4. Forbes, T. R., Endocrin., 29, 70 (1941).

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FOLLEY, S. Retarding Effect of Ghost Formation on Absorption from Subcutaneously Implanted Tablets of Hexœstrol. Nature 150, 735–736 (1942).

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