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Effect of ŒStrin Injections on the Mouse Ovary

Abstract

IN 1941 Bullough and Gibbs1 showed that, both in the mouse (Mus musculus L.) and the starling (Sturnus vulgaris L.), maximum mitotic activity in the germinal epithelium of the ovary is confined to a short period immediately following ovulation, and it was suggested that, in all probability, some hormone, coming into full operation at this time, stimulates the epithelium to produce large numbers of new oogonia. It has since been shown2 that a similar post-ovulation peak of mitotic activity is present in the ovary of the minnow (Phoxinus Iœvis L.), and that in this fish it is possible to stimulate the germinal epithelium to abnormal mitotic activity, and consequently to the production of abnormal numbers of oogonia, by abdominal injections of œstrin.

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References

  1. Bullough, W. S., and Gibbs, H. F., NATURE, 148, 439 (1941).

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  2. Bullough, W. S., J. Exp. Zool. (in the press).

  3. Bullough, W. S., J. Endocrin. (in the press).

  4. Bullough, W. S., J. Endocrin. (in the press).

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BULLOUGH, W. Effect of ŒStrin Injections on the Mouse Ovary. Nature 149, 271–272 (1942). https://doi.org/10.1038/149271b0

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