Abstract
Janes and Kelson1 have observed that glycogen storage in rats treated daily with diethyl-stilbœstrol for five days or more is at an abnormally high level. We have investigated the influence of cestrogens and other sex hormones on glycogen storage ; and also on the insulin content of the pancreas (cf. Griffiths and Young2). Data are given in Table 1, including the liver and muscle glycogen contents, after a fast of approximately 18 hr., of rats carrying subcutaneous tablets of various substances for two weeks. These results show that œstriol and œstradiol resemble diethyl-stilbœstrol in promoting glycogen storage under these conditions, although oestrone and testosterone do not. It appears that the influence of these substances on liver glycogen under such conditions is to some extent paralleled by their action in causing enlargement of the liver and an increase in pancreatic insulin; it seems possible that the latter phenomenon is secondary to the increase in glycogen storage.
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References
Janes, R. G., and Nelson, W. O., Proc. Soc. Ecep. Biol. N.Y., 43, 340 (1940).
Griffiths, M., and Young, T. G., NATURE, 146, 266 (1940).
Britton, S. W., and Silvette, H., Amer. J. Physiol., 100, 693 (1932).
Long, C. N. H., and Katzin, B., Proc. Soc. Exp. Biol., N.Y., 38, 516 (1938).
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GRIFFITHS, M., MARKS, H. & YOUNG, F. Influence of (œstrogens and Androgens on Glycogen Storage in the Fasting Rat. Nature 147, 359 (1941). https://doi.org/10.1038/147359a0
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DOI: https://doi.org/10.1038/147359a0
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